Mary Jane is a two-act dramatic stage play written by American playwright Amy Herzog.

The Broadway cast is led by Rachel McAdams in the titular role.

[2] The play is semi-autobiographical and based on Herzog's daughter Frances, who was born with nemaline myopathy and died at age 11 in 2023.

[3][4] As Mary Jane navigates both the mundane and the unfathomable realities of caring for Alex, her chronically ill young son, she finds herself building a community of women from many walks of life.

[7] The play was next staged Off-Broadway by the New York Theatre Workshop from September 6 - October 29, 2017.