Mary Jeanne Kreek (9 February 1937[1] – March 27, 2021)[2] was an American neurobiologist specializing in the study and treatment of addiction.

[3] She is best known for her work with Marie Nyswander and Dr. Vincent Dole in the development of methadone therapy for heroin addiction.

[7] In 2000, Kreek was named a Fellow of the New York Academy of Sciences, and in 2004, she received an Alumni Gold Medal Award from Columbia University College of Physicians and Surgeons for "lifetime excellence in medicine".

[6] As of November 2015, she was a senior attending physician, the Patrick E. and Beatrice M. Haggerty Professor, and head of the Laboratory of the Biology of Addictive Diseases at The Rockefeller University.

[9] Her father, Louis Francis Kreek, was an Examiner-in-Chief and served on the board of the United States Patent and Trademark Office.