Mary Lokko was a Ghanaian activist.
Lokko was active in the affairs of the West African Youth League in the 1930s, first becoming involved in discussions surrounding the Second Italo-Ethiopian War, which was then raging.
Her beliefs drew attention from local journalists, and in January 1936 I. T. A. Wallace-Johnson suggested that she become his assistant; as a result, she was perhaps the first woman in West Africa to hold an official position in a political organization.
She used her platform to support women's involvement in the Youth League.
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