Mary Lou Jepsen is a technical executive and inventor in the fields of display, imaging, and computer hardware.

She was the co-founder and first chief technology officer of One Laptop per Child (OLPC), and later founded Pixel Qi in Taipei, Taiwan, focused on the design and manufacture of displays.

She founded and led two moonshots at Google X, and was an executive at Facebook / Oculus VR,[1] leading an effort to advance virtual reality.

[3] In 2016 Jepsen founded OpenWater, a startup working on fMRI-type imaging of the body using holographic, infrared techniques.

By the end of 2005, she had completed the initial architecture, led the development of the first prototype, and signed up some of the world's largest manufacturers to produce the XO-1.

[1] In 2016, she left Facebook and founded Openwater, a firm aiming to use infrared holography to make fMRI-type imaging inside the body practical, at the price level of consumer electronics and in wearable form factors.

[32] At the IGNITION 2018 Conference, Jepsen further discussed the resolution progression of Openwater's MRI machines and the potential for the technology to make advancements in telepathy by allowing users to transmit thoughts and feelings electronically.

[33] In a 2020 online call, Mary Lou mentioned that openwater devices are actively in the rapid prototyping phase with alpha kits expected August 2020.

She has also received numerous awards for the work she did at One Laptop per Child and has been named to many other "top" lists in computing by Fast Company, New York Times, IEEE Spectrum and others.