[2] Tye was appointed the first librarian for the Abner Wellborn Calhoun Medical Library at Emory University, which opened on January 1, 1924.
[3] In 1930, she spearheaded an effort to purchase a 1543 edition of De Humani Corporis Fabrica Libri Septem by Andreas Vesalius, a landmark in the study of human anatomy.
[6][7] As Chairman of the Executive Committee, Tye also worked closely with the Committee on the Cost of Current Medical Periodicals, led by Eileen R. Cunningham, to coordinate with the American Library Association and prominent journal publishers to address the high cost of German periodicals.
[8] Then considered the world scientific leaders, German medical journals and publications made up two-thirds of the library's collection budget.
[11] These funds helped to establish the M. Myrtle Tye Special Collection for the History of Medicine, now housed at the Emory University Woodruff Health Sciences Center Library.