Keller began her career on the daytime soap operas Ryan's Hope (1982–83) and Another World (1983–1985) and later starred in a number of television sitcoms.
She starred as Laura Kelly in the Fox comedy series Duet (1987–1989) and in the show's spin-off, Open House (1989–90).
Keller later had lead roles in the short-lived sitcoms Baby Talk (1991–92), Camp Wilder (1992–93), and Joe's Life (1993).
Moving to primetime, she played the part of Laura Kelly on two Fox sitcoms, Duet (1987–1989) and its spinoff Open House (1989–90).
As of mid-1990s, Keller has made many guest appearances on television series, including Ellen, The Practice, NCIS, Criminal Minds, 24, Mad Men, Castle, The Closer, CSI: Crime Scene Investigation, Supernatural, Pretty Little Liars and Scandal.
[17] In 2011, Keller was cast as the lead character's mother in the ABC Family drama pilot Chasing Life.