Peisley preached around Ireland with Elizabeth Tomey in 1746, and toured England in 1748-50, riding 5,000 miles (8,000 km) in 29 months and attending 525 meetings.
At an annual London meeting, she, Catherine Payton and four others proposed that a separate women's group should be formed with the Quakers.
They rode 8,000 miles (13,000 km) "often through thinly inhabited country, braving dangerous creeks, swamps, and wild animals", visiting North and South Carolina, Virginia, Maryland, New England, and Pennsylvania.
[4] Peisley spoke against slavery and held meetings with African Americans,[2] writing to Quakers in Virginia in 1754 that "one thing the friends here ... were in the practice of, which gave us considerable pain ... that is, buying and keeping of slaves which we could not reconcile with the golden rule of doing unto all men as we would they should do unto us".
[1] On 17 March 1757 at Mountrath she married Samuel Neale (1729-1792), who had first heard her preach in Cork in about 1750 and had subsequently become a Quaker minister.