She held office immediately following the Second Vatican Council, a time when Roman Catholic congregations underwent drastic changes.

Regnier began the process for revising the Congregation's Constitutions to bring it into accordance with the Church's recommendations for the renewal of religious life.

Under her leadership, wearing the traditional habit became optional, and the Sisters received permission to drive cars, to handle their own correspondence, and to use electric clocks.

After her term as Superior General, Regnier spent a period of time in the Diocese of Joliet in Illinois, spending 15 years in the Marriage Tribunal there.

[2] After retiring from there in 1993, she served on staff at the health care services at Saint Mary-of-the-Woods and in prayer ministry, spending significant time in the Blessed Sacrament Chapel.