Mary Ramsey also played violin and viola for 10,000 Maniacs and sang backing vocals on the 1993 album MTV Unplugged.

The duo released two albums with the Maniacs, 1997's Love Among the Ruins, which contained a cover of the Roxy Music song "More Than This" that became a top 40 hit on the U.S. charts,[5] and The Earth Pressed Flat in 1999.

[6] While with 10,000 Maniacs, Ramsey toured throughout the U.S. and in Brazil,[6] Puerto Rico, Panama,[7] England, Portugal,[6] Germany, the Netherlands and Austria.

[10][11] In 2002, after she and Lombardo both left the Maniacs following the death of guitarist Rob Buck, John & Mary released The Pinwheel Galaxy (2003).

[12] In another project, she was joined by fellow Buffalonians Theresa Quinn, Susan Rozler, and Alison Pipitone in a group called Girls Gone Mild.