[2] Once she graduated from Oberlin, she was appointed to the faculty of the first Black high school in Washington, where she taught until her marriage to James H. Meriwether, who practiced law in the District of Columbia.
They also helped to secure home rental and ownership for other African American families in the DC area.
Her chief interest was the development and maintenance of the National Home for the Relief of Destitute Colored Women and Children, established by an Act of Congress in 1863.
Meriwether appeared before a United States Congressional Committee, and the continued existence of this organization was due largely to her efforts.
When the Young Men's Christian Association was organized in Washington, she served as president of the Women's Auxiliary.