Mary Warburg was a daughter of the Hamburg senator and merchant Adolph Ferdinand Hertz and his wife Maria, née Goßler.
They moved to Florence, where Mary Warburg entered into artistic exchange with the sculptor Adolf Hildebrand and the painter Arnold Böcklin.
Mary Warburg created drawings, pastels, watercolours – landscapes as well as portraits and figurative studies – and sculptures.
In 1930, she completed her most prominent artwork, the bust of her husband Aby Warburg, copies of which are on display in the Hamburger Kunsthalle, the Warburg-Haus in Hamburg and the Warburg Institute, London.
In spring 2022, the Ernst Barlach House in Hamburg dedicated an exhibition to her works.