[3] Wyche graduated from Henderson College in 1889, and taught in the institution's primary department during her studies.

She held a strong belief in education and made small loans to several young students which enabled them to attend college.

The result led to the formation of the North Carolina State Nurses Association the following year.

It was part of Wyche's plan to improve standards which led to the signing of a law on March 3, 1903, by North Carolina state governor Charles Brantley Aycock.

[2] In 1907, she was made the North Carolina State Nurses Association's life honorary president.

She, along with Raleigh-based resident Birdie Dunn, established a home for tubercular nurses in Black Mountain in 1913.

She led a movement to establish a pre-nursing course at the North Carolina College for Women, and was the leader in seeking to found a nursing school at Duke University.

[1][2] She died at the family home in Wychewood close to Henderson on the night of August 22, 1936.