As of the 2020 United States census, the district had a population of 107,403, of whom 83,995 (78.2%) were of voting age.

[5] The 45th district is home to Baltimore's storied Dunbar High School.

It was named in memory of Paul Laurence Dunbar, a famous African-American poet, who had died ten years earlier.

The University of Baltimore School of Law is housed in the new John and Frances Angelos Law Center, at the corner of Mount Royal Ave. and N. Charles St. on the University of Baltimore's main campus in the Mt.

The district is represented for the 2023–2027 legislative term in the State Senate by Cory V. McCray (D) and in the House of Delegates by Jackie Addison (D), Caylin Young (D) and Stephanie M. Smith (D).