MD 208 connects the northwestern Prince George's County suburbs of Cottage City, Colmar Manor, Brentwood, and Hyattsville.

(Bladensburg Road), which forms the border between the towns of Cottage City and Colmar Manor.

At the railroad bridge, MD 208 enters the town of Brentwood and its name changes to 38th Street, which intersects US 1 (Rhode Island Avenue).

State maintenance resumes at MD 208's bridge across the Northwest Branch Anacostia River, where the highway leaves Brentwood and enters the city of Hyattsville.

Hamilton Avenue continues straight to provide access to Ager Road and the West Hyattsville station on the Washington Metro's Green Line.

[12][13] The highway's bridge across Northwest Branch, which had been built in 1932, was raised to a higher level in 1956.

[16] MD 208 was removed from Mount Rainier in favor of its present route through Brentwood by 1960.