MD 216 heads southeast as two-lane undivided Scaggsville Road, which veers east in the village of Fulton and passes south of Reservoir High School.

The highway expands to a four-lane divided highway that passes through four roundabouts and heads north of a park and ride lot serving MTA Maryland commuter buses on its approach to its four-ramp partial cloverleaf interchange with US 29 (Columbia Pike) in Scaggsville.

At its intersection with Main Street, MD 216 drops to two lanes, becomes municipally maintained, and is virtually unsigned.

The highway passes east of the original site of Laurel High School at Montgomery Street and east of the Laurel Branch Library at Talbott Avenue, which is the westbound portion of the one-way pair that carries MD 198 through the city.

[6][7] Starting in 1934, MD 216 was extended east from US 1 to Fort Meade using the existing county bridge across the Patuxent River, which was repaired as part of the project.

[13] The remainder of MD 602 from near Brock Bridge Road to the entrance to Fort Meade near the Little Patuxent River was completed by 1946.

MD 216 crossed the Patuxent River in line with 9th Street in Laurel on a bridge that no longer exists.

MD 216 passed under the Baltimore and Ohio Railroad (now CSX's Capital Subdivision) and curved east to cross the Patuxent River on another defunct bridge.

The state highway's eastern end was at the entrance to Fort Meade near the Little Patuxent River.

[19] By 1963, the state highway was moved to its present course from north of the Patuxent River to Scaggsville Road near the site of the I-95 interchange.

[25] The three-legged roundabout at Old Columbia Pike was added in 2002; the one at Maple Lawn Boulevard was completed in 2004.

[27][28] The western end of the two-lane segment of highway from the US 29 interchange to Leishear Road was changed to a cul-de-sac.