MD 384 is a six-lane divided highway that forms the southernmost portion of Colesville Road, a major commuting route and one of the two main streets, with Georgia Avenue, within downtown Silver Spring, the commercial hub of southeastern Montgomery County.

The state highway also provides access to the Silver Spring station of the Washington Metro, which serves as a transit hub for commuter rail and bus service for the surrounding area.

MD 384 heads northeast as a six-lane divided highway between high-rise apartment complexes.

The highway passes underneath the Silver Spring Metro and MARC stations and immediately to the west of the Paul S. Sarbanes Transit Center, which is a hub for Metrobus, Ride On, and MTA Maryland Commuter Bus service.

[6] Colesville Road from 16th Street to Georgia Avenue was numbered MD 384 by the time the highway was widened and resurfaced in 1949.