The highway runs 11.19 miles (18.01 km) from Snug Harbor Road in Shady Side north to MD 214 in Edgewater in Anne Arundel County.

MD 468 is a J-shaped route that connects Edgewater with the Chesapeake Bay communities of Galesville and Shady Side.

MD 468 begins at an intersection with West Shady Side Road, which heads north toward the Capt.

MD 468 gradually curves to the north and crosses three streams that flow into the West River.

MD 468 passes to the west of three historic homes: Tulip Hill, which is accessed directly from the route; and Cedar Park and Parkhurst.

The former road leads east to the Smithsonian Environmental Research Center and the latter passes the historic meeting place of the South River Club.

[14] MD 468 once extended a short distance along Snug Harbor Road from its present terminus in Shady Side.