The highway connects Interstate 95 (I-95)/I-495 (Capital Beltway) to Northwest Stadium, Six Flags America, and several stations of the Washington Metro's Blue and Silver lines, which the route parallels between Capitol Heights and Largo.

MD 214 heads east as a six-lane divided highway along the northern edge of the town of Capitol Heights and crosses Henson Creek.

Just east of MD 332, the highway intersects Addison Road and passes the eponymous Metro station.

[1][2] MD 214 intersects Morgan Boulevard—which leads north to the namesake Metro station and Northwest Stadium, the home of the Washington Commanders—west of its partial cloverleaf interchange with I-95/I-495 (Capital Beltway) in Largo.

East of the freeway, the state highway has a partial interchange with Harry S. Truman Drive, which is unsigned MD 202C and leads to Downtown Largo station, which is the eastern terminal of Washington Metro's Blue and Silver lines.

East of the Western Branch of the Patuxent River, the highway intersects MD 193, which heads north as Enterprise Road and south as Watkins Park Drive.

MD 214 reduces to four lanes and passes along the southern edge of the Six Flags America amusement park.

The highways both intersect CSX's Popes Creek Subdivision rail line at-grade and cross Collington Branch before the roads reunite.

MD 214 intersects Riva Road and passes the historic home Summer Hill on its way to Edgewater.

The route gains a second eastbound lane and a median just west of its intersection with MD 2 (Solomons Island Road).

MD 214 continues east through the community of Selby-on-the-Bay, where it passes the entrance to Camp Letts and the historic home Gresham.

[1][2] MD 214 is a part of the National Highway System as an intermodal connector between the Addison Road Metro station and the Capital Beltway.

This road followed most of MD 214's present alignment from Capitol Heights to Edgewater; the major deviation was between Hall Station on the Pennsylvania Railroad (now CSX's Popes Creek Subdivision) and Davidsonville, between which the highway was planned to follow Queen Anne Bridge Road and cross the Patuxent River at the hamlet of Queen Anne, also known as Hardesty.

[5] Central Avenue was extended east from Largo to near what is now MD 193 as a 15-foot-wide (4.6 m) concrete road starting in 1919; the extension was finished by 1921.

[14] This highway was built as a 15-foot-wide (4.6 m) gravel road from the modern MD 214–MD 253 intersection east to the entrance to Camp Letts by 1923.

[35][36][37] The final gap in divided highway between Capitol Heights and US 301, from east of MD 193 to west of Hall Station, was filled in 1997.