Known as Rohrersville Road, the state highway runs 12.20 miles (19.63 km) from U.S. Route 340 (US 340) in Weverton north to US 40 Alternate in Boonsboro.

MD 67 parallels the western flank of South Mountain in southeastern Washington County, connecting Boonsboro with Weverton and Rohrersville.

In conjunction with US 340 and US 40 Alternate, MD 67 connects Hagerstown and Harpers Ferry, West Virginia, a link that made the highway one of the original state roads marked for improvement in 1909.

MD 67 begins at a trumpet interchange with US 340 (Jefferson Pike) in Weverton within the Potomac Water Gap near Harpers Ferry.

The highway parallels another loop, Mount Carmel Church Road, which leads to the Nicodemus Mill Complex, as the route crosses Dog Creek.

[9][10] The southern end of pavement remained north of Garretts Mill until the modern road was extended south through Weverton to US 340 in 1934 and 1935.