In the 1940s, the relatively small school could not accommodate the growing population of the city, caused in part by the opening of the Wills Sainte Claire automobile factory.

During construction, the basement of the school was reinforced with steel and concrete support beams so it could double as an air raid shelter.

In later years, the Detroit Pistons held summer practices in Marysville High's gym.

[7] The football team plays at Walt Braun Viking Stadium at the corner of Michigan and Collard.

Marysville High School's pool is shared with the city's recreation department.

Marysville High School operates a community television station broadcasting to residents within the district on Comcast Cable Channel 6.

Nearly all of the programs are produced by Marysville High School students, with the exception of segments distributed by St. Clair County RESA or local politicians.

M6 Television YouTube Channel Marysville High School is an active participant in FIRST Robotics Competition, having competed since 2014 as team 5167, also known as the Vi-Bots.

The volleyball team also holds a national record for the longest winning streak, in any sport.

[17] The 1983 Marysville Vikings are the only team in the history of the MHSAA to be ranked #1 in the AP Poll at the end of the regular season, remain undefeated throughout the course of the playoffs, yet not win the state championship.

The Marysville High School Cross Country team has competed in the MAC Blue Division.

The women's cross country team has made it to the MHSAA state championships for five consecutive years (2015-2018).

In 2021, The Girls swim and dive team placed first in the MAC Blue Division meet held by MHSAA.

They’re now placed in the MAC White division because of their winning streak throughout the 2021-2022 school year season.

The Marysville Viking Regiment is the high school's band program, which involves sophomores, juniors and seniors.

For the better part of the past decade, the band has competed in state finals at Ford Field in Detroit, taking second place in 2009.

Every three years, The Marysville Viking Regiment travels to Walt Disney World to perform in Disney's Magic Music Days, which includes a workshop on professional musicianship, and a parade in Magic Kingdom.