Lusha also starred alongside David Hasselhoff and Ian Ziering in SyFy's television movie Sharknado: The 4th Awakens.

Lusha starred in movies comprising a variety of genres, including Cherry Bomb (2004), My Father's Eulogy (2007), Muertas (2007), Time of the Comet (2008), Ballad of Broken Angels (2009), Kill Katie Malone (2010), Dragonfyre (2013), The Architect (2014), Of Silence (2014), Fatal Instinct (2014), and Branded (2016).

Dr. Alli was a colonel in the army during World War 2, and chief of laboratories for the United States Department of Veterans Affairs.

After a few months of professional modeling and acting in local theater plays, she was discovered by a Hollywood talent agent who held an open call in Detroit, Michigan.

[21] Upon entering the drama department, Lusha then portrayed the role of Cinderella in the play, The Last Dress Rehearsal and Belle in Beauty and the Beast.

[22][23] Then in 2000, it was Lusha's television debut with a guest appearance on the Disney Channel series Lizzie McGuire as the character Olivia in the episode "Last Year's Model".

[26] That following year, the George Lopez show won an Emmy and was established as the second-longest-running sitcom in television history to star a Hispanic lead, after I Love Lucy.

[27] Lusha won two consecutive Young Artist Awards for Best Leading Actress in a Comedy and Drama for her portrayal as Carmen.

[28] While working on George Lopez, Lusha also voiced the role of Nina for four years on the PBS series Clifford's Puppy Days.

[8] At the suggestion of George Clooney, Lusha has also appeared in the Spanish language film Muertas (2008) in which she portrayed the main character Aracelli.

[9][21][31] Lusha also starred as Saint Agnes in the Albanian production of Time of the Comet (2008) based on the novel A Difficult Year by Ismail Kadare.

In Katie Malone, she portrayed the role of Ginger, a premed college student who is tormented by the ghost of a slave girl.

[34] In 2012, Lusha starred in the film Orc Wars, portraying the role of Princess Aleya, the last remaining elven warrior.

[35] Lusha re-teamed with George Lopez creator and executive producer Bruce Helford on the FX series Anger Management.

As the national spokesperson for the Great American Bake Sale, a hunger-relief program, Lusha visits local towns throughout the United States and supports food drives to help battle childhood hunger.

[44] For her role as a national spokesperson, Lusha promotes the importance of raising funds to help local communities.

[44] Lusha founded the Children of the World Foundation, a 501(c)(3) nonprofit that offers food, shelter and education to families in deprived conditions.

[45] As an Ambassador, Lusha encouraged a dialogue between aspiring global entrepreneurs and Athgo's bodies of support such as the World Bank Group, the United Nations, and international universities.

Lusha will participate with Paul Kagame, President of the Republic of Rwanda and Dr. Hamadoun Touré, Secretary-General of ITU and vice-chairman of the Broadband Commission for Digital Development.

She later attended Glendale College, in Southern California, graduating with an AA degree and transferring to UCLA as a junior at the age of 18.

[15][21] Lusha has also earned a degree from FIDM and credits her education when designing and sewing her own clothes on the red carpet.