As the park is accessible only by a three-hour boat journey, the cyclone season (January to March) is best avoided.

The island reserve of Nosy Mangabe is one of the best sites in Madagascar to try to glimpse the elusive nocturnal aye-aye.

[citation needed] Masoala harbors many other species, such as the Madagascar day gecko, leaf-tailed gecko, chameleons of all sizes, spectacular birds such as the helmet vanga, and rare species such as the red owl and tomato frog.

Each year from July to early September, hundreds of humpback whales visit the Antongil Bay during their long migration.

The warm protected waters of the bay provide an ideal breeding and calving ground for these marine mammals.