In late 2003, the coalition of organizations that formed the Steering Committee for MassEquality hired its first staffer, Campaign Coordinator Marty Rouse.

Rouse, an experienced political operative who had helped members of the Vermont legislature recover form election losses they suffered as a consequence of supporting civil union legislation, quickly implemented a campaign to marshal the coalition's resources and build a field operation to bolster the LGBTQ movement's legislative lobbying.

The debate, conducted in a joint session of the Massachusetts House of Representatives and Senate, a Constitutional Convention that spanned four days over nearly two months, was carried live on C-SPAN.

In 2021, MassEquality moved to Worcester, to better support its shift in focus to prioritize local organizing and education, in pursuit of lived equality, statewide, in addition to its traditional lobbying and electoral activities.

[5] On February 28, 2014, following pressure on the part of Boston Mayor Martin J. Walsh, the organizers of South Boston's St. Patrick's Day Parade, which had banned open participation by gay organizations for 20 years and in 1995 won a Supreme Court case that supported their stance, announced that MassEquality would be welcome to participate in the parade.

It set conditions that MassEquality's marchers not wear shirts or carry signs that display the word gay or refer to sexual orientation.