Route 116 is a 68.26-mile-long (109.85 km) north–south (though in its northern part it is more east-west) state highway in Massachusetts.

The route junctions with the interstate officially at Exit 11, before entering the city of Chicopee.

It then turns northeastward, passing through the northwest corner of Granby before clipping South Hadley again on the way into Amherst.

It passes the western edge of UMass Amherst, passing behind Warren McGuirk Alumni Stadium and having an interchange with North Hadley Road, which connects the route directly to the university.

The route narrows to a two lane undivided road and meets the southern end of Route 63 before meeting Sunderland Road before passing into Franklin County and the town of Sunderland.

In Sunderland, Route 116 passes west of the Green Swamp and Bull Hill before crossing Route 47 again in the town center before crossing the Connecticut River a third time, over the Sunderland Bridge into Deerfield.

the route then turns westward, passing Spruce Corner on its way back into Hampshire County and the town of Plainfield.