Route 130 begins in the Santuit section of Barnstable at Route 28 and enters Mashpee 0.2-mile (0.32 km) from the terminus and travels on a north–south path through Sandwich.

The highway runs through the village of Forestdale in the southern section of the town.

Later it intersects with US 6 at exit 59 and then passes through the historic part of Sandwich, which includes such landmarks as the Dexter's Grist Mill, the Hoxie House, the Sandwich Glass Museum, and the Thorton W. Burgess Museum.

Route 130 passes Shawme-Crowell State Forest before ending at Route 6A just before the town line with Bourne east of Sagamore.

This Massachusetts road-related article is a stub.