The route is located on Cape Cod and runs through the towns of Falmouth and Mashpee.

The route provides a more direct link for those wishing to travel from North Falmouth to Hyannis.

The roadway continues west from this intersection towards Buzzards Bay, but that portion is not signed as Route 151.

Route 151 passes the village of Hatchville and the Barnstable County Fairgrounds, continuing east until it enters the town of Mashpee.

As Route 151 approaches its eastern terminus, it becomes much more heavily developed, passing between and dividing the north and south sections of the Mashpee Commons shopping center.