Route 150 is a 3.67-mile-long (5.91 km) short south–north highway entirely in Amesbury, Massachusetts.

The highway is the main south-north thoroughfare in Amesbury, and serves as a southward continuation of NH 150, connecting Amesbury to the New Hampshire town of Kensington and ultimately, Exeter.

After this intersection, Route 150 then becomes the primary thoroughfare through the center of the city, passing through the more densely populated and commercialized downtown of Amesbury.

During this section, the road splits for about one-quarter mile into two one-way segments, with the northbound and southbound sides carrying traffic through different parts of downtown before rejoining together.

After travelling through downtown Amesbury the road reaches the more rural northern section of the city and then crosses into South Hampton, New Hampshire.