Route 53 is a 22.138-mile-long (35.628 km) south–north state highway in southeastern Massachusetts.

The name comes from Anne Whiton, a local tavern owner who in the mid-1700s, along with her daughters, had an "unsavory reputation" and was called quean with the archaic meaning of the word as prostitute.

It passes through the southwestern part of that town before meeting Route 14 just over the line into Pembroke.

The two routes pass concurrently for over a mile and a half before splitting in the area of North Pembroke.

The route passes through the southwest corner of that town before entering Weymouth.