Born in the family villa in the Bosco Chiesanuova, close to Verona, he graduated from Libera Università Internazionale degli Studi Sociali Guido Carli with a master's degree in political science.

On his father's death, Moratti inherited his shares in the Saras Group, engaged in the refining of petroleum, where he is presently CEO.

Inter won the Scudetto, the Coppa Italia and the Champions League in the 2009–2010 season, becoming the first Italian team that managed to achieve the Treble.

Later, in July 1999, Moratti sanctioned a then world-record €48 million purchase of striker Christian Vieri, and has purchased numerous others, including Roberto Carlos, Hernán Crespo, Adriano, Iván Zamorano, Maicon, Roberto Baggio, Zlatan Ibrahimović, Luís Figo, Patrick Vieira, Samuel Eto'o, Alvaro Recoba and Wesley Sneijder.

Before Mancini, Moratti employed more than ten short-lived coaches, including Roy Hodgson, Marcello Lippi, Marco Tardelli, Héctor Cúper and Alberto Zaccheroni.

The next day after Ranieri was dismissed, chief scout of the first team Giovanni Battista Lanfranchi was fired and replaced by the former technical commission of Udinese, Valentino Angeloni.

sold all its stake in Inter Milan to Erick Thohir's Nusantara Sports Ventures HK Limited for €60 million (and re-sold to Zhang Jindong's Suning Holdings Group).