The settlers were young pioneers from Hungary, Czechoslovakia, and Germany who arrived before World War II.

[3] The settlers of Masu'ot Yitzhak rose to the challenge of living in the Judean Mountains, building homes and planting orchards.

[4] After their return from captivity in 1949, the Masu'ot Yitzhak pioneers established a new moshav of the same name near Shafir, a region inhabited by the Philistines in biblical times.

Shafir had served as a base for the southern front of the Israeli army during the 1948 war,[5] and the land on which the new Masu'ot Yitzhak was founded had until shortly beforehand belonged to the depopulated Palestinian village of al-Sawafir al-Gharbiyya.

A reservoir was built 40 years ago to harness the winter flood waters of Nahal Lachish for farming.