The eighth version of the Masters of Evil debuted in Secret Avengers #21.1, created by Rick Remender, Patrick Zircher, and Andy Troy.

The ninth version of the Masters of Evil debuted in Thunderbolts #10, created by Jim Zub, Jon Malin, Kurt Busiek, and Mark Bagley.

The original Masters of Evil (consisting of existing Marvel Comics supervillains the Black Knight, the Melter, and the Radioactive Man) was gathered by former Nazi scientist Baron Heinrich Zemo.

[10] In a later issue, Zemo kidnaps Rick Jones with an attractor beam and has the Enchantress and the Executioner release the Black Knight and the Melter (the Radioactive Man having been deported back to China).

[12] The second version, organized by the robot Ultron-5 (under the alias the Crimson Cowl), consisted of the second Black Knight,[13] Klaw, the Melter, the Radioactive Man and Whirlwind.

[14] Criminal scientist Egghead organized a third version, consisting of Moonstone, the original Scorpion, Tiger Shark and longtime member Whirlwind.

After the team's defeat, Egghead kept only Moonstone and Tiger Shark; the Scorpion and Whirlwind were replaced with the original Beetle, the Shocker, and veteran member the Radioactive Man.

Baron Helmut Zemo formed the fourth version of the Masters of Evil from over a dozen villains, consisting of the Absorbing Man, Blackout, Black Mamba, the Fixer, Goliath, the Grey Gargoyle, Mister Hyde, Moonstone, Screaming Mimi, Tiger Shark, Titania, Whirlwind, the Wrecking Crew (Bulldozer, Piledriver, Thunderball and the Wrecker), and Yellowjacket, created with the goal of overwhelming the Avengers with sheer raw power, whereas others had attempted to match the current line-up.

Its roster included Gargantua, Jackhammer, Oddball, Powderkeg, and Puff Adder, in addition to former members the Absorbing Man, the Shocker, Titania, and Yellowjacket.

The eighth incarnation,[25] led by the Crimson Cowl, consisted of Black Mamba, the Cardinal, the Cyclone, Gypsy Moth, Hydro-Man, the Machinesmith, and Man-Killer.

Max Fury of the Shadow Council forms a ninth incarnation of the Masters of Evil, consisting of Princess Python, Vengeance, and Whiplash.

[26] Max Fury later recruits the Black Talon, the Brothers Grimm, Carrion, the Constrictor, Crossfire, Diablo, Firebrand, the Griffin, Killer Shrike, Lady Stilt-Man, the Pink Pearl, and the Squid to join the Shadow Council's Masters of Evil.

[33] The Anachronism, Cammi, Chase Stein, Death Locket, Hazmat, and Nico Minoru teleport to Bagalia in disguise and locate Cullen Bloodstone at the Hole (a Bagalian bar owned by Arcade).

The Constrictor and Madam Masque arrange for Cullen to teleport the group to a nearby swanky party at Massacrer Casino hosted by Arcade so that they can get revenge on him once and for all.

As they retreat, Black Skull has Ghost Goblin dump his Noggin Bombs which are annulled when Star Brand matures and negates their explosions.

As the Deathlok reaches the brain of Avengers Mountain to put out a distress signal on what happened on Earth-616, Black Panther, Valkyrie, and Namor continue their fight against Doom Supreme and Kid Thanos until they retreat.

Far from Avengers Mountain, Doom Supreme and Kid Thanos meet up with Iron Inquisitor and Mephisto in the form of a dog as he nears the corpse of Orb.

Robbie and his Deathlok companion are later rescued from Black Skull by Ant-Man and his resistance consisting of Vision, Moon Knight (Mariama Spector), Wonder Man, and Infinity Thing.

With help from the granddaughters of King Thor, Robbie, his Deathlok companion, and the Resistance defeated Black Skull and his alternate counterparts while liberating Earth-818.

[47] When the Multiversal Masters of Evil conquer another Earth and plan to return to Earth-616, Ghost Rider arrives where he controls Black Skull's symbiote enough to subdue King Killmonger and uses his Hell Charger to knock down Kid Thanos and Hound before it drags Dark Phoenix.

When Dark Phoenix notes that this Earth is taking longer to conquer, Doom Supreme starts to cast a spell to wipe out the ancestral ape-men as Prehistoric Ghost Rider ends up one of the victims.

[51] Amidst the energies from the ancient Multiverse being leaked through, Doom Supreme is turned to stone by a sample of it and is shrunken by Ant-Man of Earth-818 while Dark Phoenix is slain by Firehair and Echo.

After the Black Knight, Crimson Dynamo, and Titanium Man are killed by Doctor Doom's Doombots, Whirlwind leaves the group to start a new life.

[65] While taking over the Central American country of Santo Rico, its dictators Madison and Lionel Jeffries kill two of the Wrecking Crew, Bulldozer and Piledriver.

[66] Though the group succeed in killing the Jeffries in turn, Magneto and Sebastian Shaw expose the Masters of Evil's criminal pasts, leading to Cobra, Crossbones, Hyde, Chemistro, the Wizard, and Wrecking Crew member Thunderball abandoning the remaining members, most of whom are killed by the Red Guard, though Absorbing Man throws Titania to safety.

[69] Additionally, a group called the New Masters of Evil appear in Marvel Adventures: The Avengers #16, consisting of Egghead, Man-Bull, the Melter, and Whirlwind.

[70] A future incarnation of the Masters of Evil from Earth-2099 appear in the Marvel 2099 story Spider-Man 2099: Exodus #3, consisting of the Patriot, the Black Knight, Baron Zemo, the Enchantress, the Melter, and the Radioactive Man.

After Zemo kills the Black Knight for disobeying orders, the Masters of Evil are defeated by the New Avengers and remanded to a prison on the planet Wakanda.

[71] A group based on the Masters of Evil called the Liberators appear in Ultimates 2, formed by Loki under the alias of Norwegian scientist "Gunnar Golman" and consisting of Chang Lam / Abomination, Crimson Dynamo, Schizoid Man, Colonel Abdul al-Rahma, Hurricane, Insect Queen, and Perun.

They received support from international governments, such as China, France, Iran, North Korea, Syria, and later Russia, and other superpowered individuals such as Natasha Romanoff / Black Widow, Hank Pym, and his Ultron / Vision II sentries to invade the United States.