The book chronicles the early lives and work of two American sexologists, Dr. William Masters and Virginia Johnson, who studied human sexuality from 1957 to the 1990s.

The 2013 Showtime television series Masters of Sex, starring Michael Sheen and Lizzy Caplan, is based on the book.

Debby Applegate described the biography as "a terrific book about the unlikely couple who touched off the sexual revolution.

The New York Times commended Maier's writing style and sense of humor.

This article about a biographical or autobiographical book published in the United States is a stub.