The fourth and final season of the American television drama series Masters of Sex premiered on September 11, 2016, and concluded on November 13, 2016, consisting of 10 episodes.

[2] The series was developed for television by Michelle Ashford and is based on the biography Masters of Sex: The Life and Times of William Masters and Virginia Johnson, the Couple Who Taught America How to Love by Thomas Maier.

Masters of Sex tells the story of Dr. William Masters (Michael Sheen) and Virginia Johnson (Lizzy Caplan), two pioneering researchers of human sexuality at Washington University in St. Louis, Missouri.

The series was renewed for a 12-episode fourth season on August 11, 2015, by Showtime;[3] however, the episode count was later reduced to 10.

[4] In June 2016, production began in Los Angeles and several recurring roles for the season were announced, including Niecy Nash, Betty Gilpin,[5] Erin Karpluk,[6] Alysia Reiner, Jeremy Strong, Ashley Zukerman,[7] and David Walton.