Matabeleland North is divided into seven districts, has its capital in Lupane, and Victoria Falls and Hwange its largest towns.

The Zimbabwean side of Victoria Falls, a World Heritage Site and major tourist attraction, is located in Matabeleland North.

The land is also less fertile than other provinces, as commercial crops cannot be grown and rural farmers usually cannot produce enough maize to feed their families.

The upper reaches of the Nata River flow through Matabeleland North before entering Botswana to discharge to the Makgadikgadi Pans.

However, the most famous geographic feature of Matebeleland North is Victoria Falls, the world's largest waterfalls that are located on the Zambezi river on the northern border of the province.