His research encompasses different concepts within the field of computer architecture, a discipline in which he has published more than 700 papers in journals, conference proceedings, and books.

Valero has combined his academic work with establishing and managing centres for high-performance computing research and technology transfer to businesses.

In 2013 he won a European Research Council Advanced Grant[3] to carry out the RoMoL project on new techniques to build multicore chips and the supercomputers of the future.

[citation needed] Valero maintains strong links with his home town, Alfamén, which has bestowed a variety of honours upon him.

In 1998 he was chosen as the municipality's "Favourite Son" and in 2005 a local school was given the name CEIP[further explanation needed] Mateo Valero.