Matherville is a village in Mercer County, Illinois, United States.

Lake Matherville, a small reservoir, is in the northwest corner of the village.

There were 301 housing units at an average density of 767.6 per square mile (296.4/km2).

Matherville is part of the Sherrard Public Library District.

Matherville is served locally by the Library District Bookmobile one day a week, with a stop at the Old School Park.