[3] At the 2014 Maria Lenk Trophy in São Paulo, Santana broke the Junior world record twice in the 100-metre freestyle, with a time of 48.85 in the heats and 48.61 in the final.

He qualified for the 2014 Pan Pacific Swimming Championships, but decided not to participate in this tournament due to the 2014 Summer Youth Olympics.

[11][12] At the 2015 World Aquatics Championships in Kazan, Santana finished 4th in the Men's 4 × 100 metre freestyle relay, again along with Marcelo Chierighini, Bruno Fratus and João de Lucca.

[16][17] He also finished 6th in the 4 × 100 metre mixed freestyle relay, along with Bruno Fratus, Larissa Oliveira and Daynara de Paula, breaking the South American record with a time of 3:25.58.

[19] At the 2018 FINA World Swimming Championships (25 m) in Hangzhou, China, Santana, along with César Cielo, Marcelo Chierighini and Breno Correia, won the bronze medal in the Men's 4 × 100 metre freestyle relay, with a time of 3:05.15, setting a South American record.