The Mathewson Block is a historic commercial building at 101 Main Street in the center of Lyndonville, Vermont.

Built in 1869, it was the first brick commercial building erected in Lyndonville, which was founded in 1866.

A decorative brick cornice and parapet extend along the top of the building on the front and sides.

[2] The village of Lyndonville was established in 1866, after a fire extensively damaged railroad facilities in St. Johnsbury to the south, and railroad executives decides to relocate rail facilities to this area.

The building was an immediate success, housing commercial tenants even before it was finished, with an auditorium space for social meetings on the upper floor.