Mathilde Hupin-Debeurme (born March 30, 1984) is a Canadian orthopaedic surgeon and former cyclist who competed in cross-country, mountain, road, and track events.

[10] Hupin finished third in the cadet category of the cross-country race held as part of the third round of the Canada Cup mountain bike competition in Mont-Tremblant the following June.

[4] At the 2001 Gary Fisher Provincial Cup held in Bromont in May that year, she placed fourth in the senior elite category by cyclist aged between 19 and 29.

[14] In London, Ontario, Hupin was the Quebec cycling team's cadet,[15] and she partook in the cross-country, criterium, road race and time trial competitions.

[1] Hupin finished 31st out of 70 entrants in the women's race of the 2005 UCI Mountain Bike World Cup stage held in Mont Sainte-Anne.

At the 2007 Pan American Games held that November in Cali, Colombia, she placed fifth in the road race, seventh in the kilometre, eighth in the track pursuit and ninth in the time trial.

[26] In 2009, Hupin and Ouellet won each of the women's kilo and pursuit races for visually impaired cyclists of the Canadian National Track Championships for Riders with a Disability.

[1][31] Hupin was part of the Dream project involving children from the ages of 7 to 17 playing a virtual reality game to reduce their anxiety and pain when medical procedures are being performed on them in hospital.