The school was under the auspices of the Roman Catholic Archdiocese of Boston.

The campus fronts on Matignon Road, Cambridge, extending into the city of Somerville at its rear.

The Cambridge Matignon School is named after Father Francis Anthony Matignon, who was born in Paris on November 10, 1753, and came to the United States after being ordained a priest.

In 1945, the high school was established by Richard Cardinal Cushing (then Archbishop of Boston).

The program has produced 19 NHL draft picks overall; however, its last tournament win was back in 2004.