She edited the Culture and Nation supplement of the newspaper Clarín,[1] as well as Ñ Magazine [es].

Matilde Sánchez studied at the Escuela Superior de Comercio Carlos Pellegrini.

In 1992 she published her first novel, La ingratitud, dedicated to her father and that takes place in Berlin.

[2] The subject of travel is recurrent in her work, and according to writer Silvia Hopenhayn [es], "appears as a fundamental experience" from her first novels.

[1] Her works have received favorable criticism from other writers, such as the Mexican Carlos Fuentes, who rated La ingratitud, El dock, and El desperdicio as particularly notable,[3] and Beatriz Sarlo, who wrote about La ingratitud: "It's a text notable for its intelligence, for the steadfast security of writing without hesitation, and for the ability to exhibit a drama of feelings with the same distance as observing a foreign city.