The firm invests in seed and early-stage companies in the United States and India, particularly in the software, communications, semiconductors, data storage, Internet or wireless sectors.

The firm is headquartered in Palo Alto, California with an additional office in Cambridge, Massachusetts.

[8] In November 2021, The Wall Street Journal reported that Matrix Partners is a major investor in Chinese semiconductor firms, raising U.S. national security concerns.

[10] In August 2023, the firm led a $3.5 million seed round for Wootz.work global sourcing platform for custom engineering equipment and solutions.

[12] In April 2024, AI platform SiftHub raised $5.5 million in a round led by Matrix Partners India and Blume Ventures.