He graduated from a beauty school and was training to be a beautician when, inspired by LGBT activists, he changed careers and became an editor and writer for the Japanese gay magazine Badi.

[5] The television debut of Matsuko Deluxe came in 2000, on Fuji TV's late-night variety show Ebunai [ja].

In his 2005 book Shūkan josō ritānzu (週刊女装リターンズ, The Weekly Cross-Dresser Returns), Matsuko writes that in 2000 his bust/waist/hip measurements were 140 centimetres (55 in) each and his weight was 140 kilograms (310 lb).

[11] As of 2022, Matsuko is a regular panelist and sometimes host on the Japanese talk shows Goji ni Muchū!, Honma Dekka!?

[14] In 2012, Matsuko participated in a debate on national pride of Chinese, Korean, and Japanese and when a Korean-Japanese guest claimed "Japanese entertainment is like field baseball, but Korean entertainment is like professional baseball", he replied that K-pop was "nothing but an imitation of American pop music".