Matsumotokiyoshi Co., Ltd. (株式会社マツモトキヨシ, Kabushiki gaisha Matsumoto Kiyoshi) is a Japanese drugstore chain founded in 1932.

Stores in other regions are operated by Matsumotokiyoshi Group companies.

The company also operates multiple pharmacies with dispensaries across the country.

[2] As of 2024, there are outlets in Thailand, Taiwan, Singapore, Vietnam, Malaysia and Hong Kong.

In 1987, the company expanded its product offering, which previously only included drugs for people in ill health, to include cosmetics and personal care products.