Matsusaka Station (松阪駅, Matsusaka-eki) is a union passenger railway station in the city of Matsusaka, Mie Prefecture, operated jointly by Central Japan Railway Company (JR Central) and Kintetsu.

On August 17, 1912, the Mie Electric Railway began operations at Matsusaka Station.

On March 27, 1930, Sangu Kyuko Electric Railway Co. connected to Matsusaka Station.

The station was transferred to the control of the Japan National Railways (JNR) Kisei Main Line on July 15, 1959.

The station was absorbed into the JR Central network upon the privatization of the JNR on April 1, 1987.