Shima-Isobe Station is served by the Shima Line, and is located 57.5 rail kilometers from the terminus of the line at Ise-Nakagawa Station.

The station was consists of a single island platform and a single island platform serving three tracks, connected to an elevated station building by footbridges.

Shima-Isobe Station opened on July 23, 1929, as Hasama Station (迫間駅, Hasama eki) on the Shima Electric Railway.

The line was one of six private companies consolidated into Mie Kotsu by order of the Japanese government on February 11, 1944.

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