The expressway is numbered E11 between Kawanoe Junction and Matsuyama Interchange and E56 between Matsuyama and Uwajima-Kita Interchanges under the MLIT's "2016 Proposal for Realization of Expressway Numbering.

[1] The first section of the Matsuyama Expressway to open was between Zentsuji and Mishima-Kawanoe interchanges on 16 December 1987.

The final section of the expressway (16.3 km between Seiyo-Uwa and Uwajima-Kita interchanges) was opened on 10 March 2012.

These sections are not classified as national expressways but rather as national highways for motor vehicles only with national expressway concurrency (高速自動車国道に並行する一般国道自動車専用道路, Kōsoku Jidōsha Kokudō ni Heikōsuru Ippan Kokudō Jidōsha Senyō Dōro).

Therefore, the distance and exit numbers continue from the sequence of the Takamatsu Expressway, starting at 56.8 kilometres (35.3 mi).