Bissonette has played bass with performers such as David Lee Roth (1987–1992), Jeff Lynne and ELO (2001), Ringo Starr (2003–2005), Elton John (2012–2023).

While on tour with Roth, Bissonette sang the difficult high harmonies made famous in VH classics, such as "Runnin' with the Devil".

In 1989, Bissonette relocated to Vancouver with Roth, his brother Gregg, guitar prodigy Jason Becker and guitarist Steve Hunter, to record the Billboard top 20 album A Little Ain't Enough.

[3] Bissonette played with Beatles tribute supergroup Yellow Matter Custard, which performed a handful of shows in 2003 and 2011.

In June 2005, the Bissonette brothers once again backed Starr at live shows at Irving Plaza in New York City in June 2005; the Genesee Theatre in Waukegan, IL for the PBS show SoundStage; and the El Rey Theatre in Los Angeles, CA, as well as on several US TV appearances (CBS This Morning, etc.)