Prior to the game, Cain and professional golfer Dustin Johnson hit golf balls from home plate into McCovey Cove.

In June 1880, Lee Richmond and John Montgomery Ward both threw perfect games; in May 2010 Dallas Braden and Roy Halladay both accomplished the feat.

[5] It was the first Giants no-hitter since left-hander Jonathan Sánchez threw one on July 10, 2009, against the San Diego Padres at AT&T Park.

The final out was made by Astros pinch-hitter Jason Castro, who hit his first career Major League home run off of Cain.

Arias successfully made the long throw across the diamond to first baseman Brandon Belt, who then tucked the ball in his back pocket before joining his teammates on the mound in celebration.

Matt Cain, the first in all those many years, to pitch a perfect game.I knew that I hadn't given up a hit early in the game, whether it was the third or fourth inning.

[11]Cain's cleats, hat, uniform, dirt taken from the pitcher's mound, and a ball from the game will be included in an exhibit in the National Baseball Hall of Fame and Museum.

Lincecum's first no-hitter came only eleven days after being the losing pitcher when the Giants were no-hit by Homer Bailey of the Cincinnati Reds.