He has played with various artists, including Pearl Jam, Edie Brickell & New Bohemians, David Bowie, Tori Amos, The Wallflowers, Elton John, Fiona Apple, Bob Dylan, Brandi Carlile, Garbage, Macy Gray, and Soundgarden.
[1] He began learning how to play the drums at 15 years old, taking lessons with David Garibaldi from the band Tower of Power.
He played over 51 shows with them through South America, Europe and a co-headlining tour with Nine Inch Nails in the United States.
Chamberlain joined Bob Dylan's Never Ending Tour in 2019 and played on his 2020 release Rough and Rowdy Ways.
[7][8] as leader with Critters Buggin with Floratone (Bill Frisell, Tucker Martine & Lee Townsend) with Sean Watkins & Matt Chamberlain Duo with Slow Music Project (Bill Rieflin, Robert Fripp, Peter Buck, Fred Chalenor, Hector Zazou, Matt Chamberlain) with Painted Shield as a sideman with Bob Dylan with A Perfect Circle with Amos Lee with Brandi Carlile with Perfume Genius with Brad Mehldau with Bruce Springsteen with Jars of Clay with Shelby Lynne with Kanye West with Leonard Cohen with Chris Cornell with The Wallflowers with Chris Isaak with Stevie Nicks with David Bowie with Edie Brickell and New Bohemians with Elton John with Fiona Apple with Frank Ocean with John Mayer with Laura Marling with Mac Miller with Macy Gray with Of Montreal with Phantogram with Peter Gabriel with Randy Newman with Robbie Williams with Sara Bareilles with Sam Phillips with Rufus Wainwright with Sean Lennon with Tori Amos with Willie Nelson and Miranda Lambert with The Who with Lorde with Amber Arcades with Zola Jesus with Ghost